Case 1

• Patient 1 was a 60-year-old male with diabetes, heart failure, peripheral arterial disease, and a 25.2 cm2 foot ulcer secondary to abscess drainage. 
• On initial presentation, bone and tendons were exposed, and necrotic tissue was present. 
• After thorough debridement and antibiotic management, PLA matrices were applied weekly, leading to full closure after 12 weeks. 
• No tendons were lost, and the foot regained full function.

Case 2

• Patient 2 is a 47-year-old type 1 diabetic individual with an open heel ulcer for the past 2 years. 
• The patient was diagnosed with osteomyelitis and underwent several antibiotic courses.  
• After the last one, PLA matrices were applied to the wound bed, which was fully closed after 7 weeks. 
• No further osteomyelitis episodes were documented.

Case 3

• Patient 3 is a 35-year-old female with diabetes, obesity, and an acute plantar wound. 
• Previous wounds on this patient led to non-healing and required amputations, so the decision was made to use PLA matrices immediately. 
• Complete closure was obtained after 9 weeks of treatment without any complications.

Case 4

• Patient 4 is a 56-year-old male with a history of heavy smoking and Lyme disease who underwent a peroneal tendon repair. 
• The post-surgical wound experienced dehiscence and tendon exposure. 
• PLA matrices were used to protect the tendons and promote wound healing. 
• After 15 weeks of treatment, the wound was completely healed, and the foot showed a normal range of motion.

Case 5

• Following the application of PLA matrices, ulcer healing improved significantly in most patients. 
• The matrices induced a robust healing response characterized by the deposition of large content of granulation tissue and the apparition of thick epithelial borders in the wound’s edge. 
• In line with these findings, the oxygen saturation of the wound bed increased over time, as well as the temperature of the peri-wound area.