Patient 1 was a 60-year-old male with diabetes, heart failure, peripheral arterial disease, and a 25.2 cm2 foot ulcer secondary to abscess drainage.
On initial presentation, bone and tendons were exposed, and necrotic tissue was present.
After thorough debridement and antibiotic management, PLA matrices were applied weekly, leading to full closure after 12 weeks.
No tendons were lost, and the foot regained full function.
Patient 2 is a 47-year-old type 1 diabetic individual with an open heel ulcer for the past 2 years.
The patient was diagnosed with osteomyelitis and underwent several antibiotic courses.
After the last one, PLA matrices were applied to the wound bed, which was fully closed after 7 weeks.
No further osteomyelitis episodes were documented.
Patient 3 is a 35-year-old female with diabetes, obesity, and an acute plantar wound.
Previous wounds on this patient led to non-healing and required amputations, so the decision was made to use PLA matrices immediately.
Complete closure was obtained after 9 weeks of treatment without any complications.
Patient 4 is a 56-year-old male with a history of heavy smoking and Lyme disease who underwent a peroneal tendon repair.
The post-surgical wound experienced dehiscence and tendon exposure.
PLA matrices were used to protect the tendons and promote wound healing.
After 15 weeks of treatment, the wound was completely healed, and the foot showed a normal range of motion.
Following the application of PLA matrices, ulcer healing improved significantly in most patients.
The matrices induced a robust healing response characterized by the deposition of large content of granulation tissue and the apparition of thick epithelial borders in the wound’s edge.
In line with these findings, the oxygen saturation of the wound bed increased over time, as well as the temperature of the peri-wound area.
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