Increased proliferation of cultured human fibroblasts by exogenous lactate is mediated by oxidant production.

A new skin substitute was developed from a synthetic copolymer mainly based on DL-lactic acid; it is marketed as SUPRATHEL®. Within the scope of a bicentric study SUPRATHEL® was compared versus paraffin gauze intraindividually applied on split skin donor sites

Lactate induces a biochemical “perception” of hypoxia and instigates several signals that activate growth factor/cytokine signals while the continued presence of molecular oxygen allows endothelial cells and fibroblasts to reproduce and deposit collagen.

A prospective, randomized, two center clinical study was conducted to evaluate the impact on wound healing of SUPRATHEL® in donor sites of split-thickness skin grafts.

A prospective, randomized, bicentric, nonblinded, clinical study was conducted to evaluate the impact on wound healing of SUPRATHEL® in partial-thickness burn injuries.  The study focused on patient pain score, healing time, analysis of wound bed, ease of care, and treatment costs.

Lactate activated Akt in endothelial cells by promoting ligand-dependent activation of multiple RTKs.

The topical application of AHAs modulates the secretion of cytokines by keratinocytes.

Lactate stimulates endothelial cell migration and tube formation in vitro, as well as the recruitment of circulating vascular progenitor cells and vascular morphogenesis in vivo.

Preexposure of U937 macrophage-like cells to sodium lactate increased LPS-stimulated matrix metalloproteinase (MMP)-1, IL-1beta, and IL-6 secretion.

Inactivation of HIF-1 hydroxylation by glucose-derived 2-oxoacids underlies the prominent basal HIF-1 activity commonly seen in many highly glycolytic cancer cells.

Evidence that lactate and pyruvate regulate hypoxia-inducible gene expression independently of hypoxia by stimulating the accumulation of hypoxia-inducible Factor 1alpha (HIF-1alpha).

Comparison of SUPRATHEL® and allograft skin in the treatment of a severe case of toxic epidermal necrolysis.

Endothelial cells respond to lactate by increasing the production of VEGF and modulating its angiogenic potency through poly-ADP ribosylation (PAR)-dependent mechanism and thereby switch over to angiogenic phenotype.

Modulation of lactate levels may provide a means to modulate collagen production.

Comparable outcomes with the gold standard of autologous skin grafting in terms of skin elasticity.

Elevated concentration of lactate in wounds is a major signal for collagen synthesis and repair.

A prospective randomized and match pairing study comparing the effect of treatment with a hydrofiber dressing with silver (HFAg) and a polylactide membrane (PLM) on systemic oxidative stress in systemic inflammatory reaction in thermal burn injuries in children.

Collagen synthesis in mouse cells.

SUPRATHEL® is easy to apply, does not require any additional antimicrobial coverage and may be used to successfully manage deeper partial-thickness burns, donor sites or burns in areas of contour, where many other dressings might not be considered or be appropriate.

Polylactide membrane controls inflammation earlier in both systemic and burn tissue, and increased the level of TGF-β3, which may be associated with the prevention of the development of hypertrophic scar in the burn wound.

Redox changes associated with the alteration of cellular nicotinamide adenine dinucleotide and polyadenosine diphosphoribose are involved in lactate-mediated VEGF expression.