Wound closure matrix
Using the same SUPRA EPT™ developed for SUPRATHEL®, PMI has developed SUPRA SDRM®CW as a proven wound closure matrix optimized to manage difficult-to-heal wounds. SUPRA SDRM®CW combines the benefits of the microporous structure found in SUPRATHEL® – which creates a protective barrier allowing the wound to heal – with additional larger pores that enable ingrowth of blood vessels needed to manage chronic and difficult-to-heal wounds.
Single application
SUPRA SDRM®CW is a single application product that is applied directly to a disinfected and debrided wound bed, where it stays intact until the wound is completely healed. After it is applied, the matrix becomes translucent and makes inspection of the healing process possible.
Pore size distribution
SUPRA SDRM®CW has the ideal pore size distribution for rapid wound healing:
- The small pores (3 – 12 μm) aid in initial cell migration;
- While the large pores (50 – 600 μm) and high porosity lead to cell attachment and vascularization.1-3
Indications
SUPRA SDRM®CW is indicated for use in the management of:
- Venous ulcers
- Arterial ulcers
- Diabetic wounds
- Mixed ulcers
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Cell Migration
Ideal pore size distribution of SUPRA SDRM®CW for wound healing in μm. Vascularization increases with pore sizes bigger than 50 μm.1–3
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SUPRA SDRM®CW
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Collagen
Average number of weeks for SUPRA SDRM®CW to achieve full healing compared to collagen.4
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SUPRA SDRM®CW
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Collagen
Cumulative incidence of healing of SUPRA SDRM®CW and collagen after 12 weeks.4
Composition
SUPRA SDRM®CW is purely synthetic and therefore does not bear any residual risks as can be the case with biological products of human or animal origin. PMI’s SUPRA EPT™ incorporates a unique and proprietary copolymer which leaves only CO2 and H2O as resorption byproducts.
SUPRA SDRM®CW incorporates a bimodal foam membrane structure having the optimal combination of small and large pores based on literature – smaller pores aid in cell migration while the larger interconnected pores aid in vascularization. This unique bimodal pore structure is proprietary to PMI.
Polymer:
Lactide-base copolymer
Metabolism:
Hydrolytically (to CO2 and H2O)
Thickness:
1.5 – 2.1 mm
Sterilization:
Gamma sterilization
Porosity:
> 85%, pores 3 – 600μm
Clinically proven
In a recent prospective randomized trial, SUPRA SDRM®CW led to faster healing rates compared to collagen dressings.4
- PLA Matrices reduced the required time for wound healing of diabetic foot ulcers by 44% when compared to collagen-based dressings.
- Moreover, 90% of wounds treated were closed by 12 weeks compared to only 30% in the collagen group.
Support materials
Contact local representative for additional materials.
SUPRA SDRM®CW is available in many configurations to accommodate different wound types for each patient.
1 Bruzauskaite et al. Cytotechnology. 2016 May;68(3):355-69 | 2 Chiu et al. Biomaterials. 2011 Sep;32(26):6045-51 | 3 Artel et al. Tissue Eng Part A. 2011 Sep;17(17-18):2133-41 | 4 Liden et al. Wounds. 2023 Aug;35(8):E257-60