SELECTED PUBLICATIONS
Publication
Summary
Beckert et al. Wound Repair Regen. 2006 May-Jun;14(3):321-4.
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Lactate-mediated increase in cellular migration is regulated by VEGF.
Constant et al. Wound Repair Regen. 2000 Sep-Oct;8(5):353-60.
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Redox changes associated with the alteration of cellular nicotinamide adenine dinucleotide and polyadenosine diphosphoribose are involved in lactate-mediated VEGF expression.
Demircan et al. Ulus Travma Acil Cerrahi Derg. 2021 Jan;27(1):122-31.
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Polylactide membrane controls inflammation earlier in both systemic and burn tissue, and increased the level of TGF-β3, which may be associated with the prevention of the development of hypertrophic scar in the burn wound.
Everett et al. J Wound Care. 2015 Jul;24(7):S4-8.
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SUPRATHEL® is easy to apply, does not require any additional antimicrobial coverage and may be used to successfully manage deeper partial-thickness burns, donor sites or burns in areas of contour, where many other dressings might not be considered or be appropriate.
Green et al. Nature. 1964 Oct 24:204:347-9.
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Collagen synthesis in mouse cells.
Gurunluoglu et al. J Burn Care Res. 2019 Jun 21;40(4):444-50.
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A prospective randomized and match pairing study comparing the effect of treatment with a hydrofiber dressing with silver (HFAg) and a polylactide membrane (PLM) on systemic oxidative stress in systemic inflammatory reaction in thermal burn injuries in children.
Hunt et al. Am J Surg. 1978 Mar;135(3):328-32.
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Elevated concentration of lactate in wounds is a major signal for collagen synthesis and repair.
Keck et al. Burns. 2012 May;38(3):388-95.
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Comparable outcomes with the gold standard of autologous skin grafting in terms of skin elasticity.
Klein et al. J Hand Surg Am. 2001 Sep;26(5):847-54.
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Modulation of lactate levels may provide a means to modulate collagen production.
Kumar et al. J Cell Physiol. 2007 May;211(2):477-85.
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Endothelial cells respond to lactate by increasing the production of VEGF and modulating its angiogenic potency through poly-ADP ribosylation (PAR)-dependent mechanism and thereby switch over to angiogenic phenotype.
Liden et al. Wounds. 2023 Aug;35(8):E257-60.
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Randomized prospective clinical trial comparing SUPRA SDRM® with collagen dressings in diabetic foot ulcers.
Lindford et al. Burns. 2011 Nov;37(7):e67-72.
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Comparison of SUPRATHEL® and allograft skin in the treatment of a severe case of toxic epidermal necrolysis.
Lu et al. J Biol Chem. 2002 Jun 28;277(26):23111-5.
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Evidence that lactate and pyruvate regulate hypoxia-inducible gene expression independently of hypoxia by stimulating the accumulation of hypoxia-inducible Factor 1alpha (HIF-1alpha).
Lu et al. J Biol Chem. 2005 Dec 23;280(51):41928-39.
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Inactivation of HIF-1 hydroxylation by glucose-derived 2-oxoacids underlies the prominent basal HIF-1 activity commonly seen in many highly glycolytic cancer cells.
Nareika et al. Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E534-42.
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Preexposure of U937 macrophage-like cells to sodium lactate increased LPS-stimulated matrix metalloproteinase (MMP)-1, IL-1beta, and IL-6 secretion.
Porporato et al. Angiogenesis. 2012 Dec;15(4):581-92.
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Lactate stimulates endothelial cell migration and tube formation in vitro, as well as the recruitment of circulating vascular progenitor cells and vascular morphogenesis in vivo.
Rendl et al. Br J Dermatol. 2001 Jul;145(1):3-9.
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The topical application of AHAs modulates the secretion of cytokines by keratinocytes.
Ruan et al. J Biol Chem. 2013 Jul 19;288(29):21161-72.
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Lactate activated Akt in endothelial cells by promoting ligand-dependent activation of multiple RTKs.
Schriek et al. Eur Burn J. 2022 Dec;3(1):1–9.
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SUPRATHEL® significantly reduced the need for transplantation by 65.5% compared to standard of care.
Schwarze et al. Ann Plast Surg. 2008 Feb;60(2):181-5.
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A prospective, randomized, bicentric, nonblinded, clinical study was conducted to evaluate the impact on wound healing of SUPRATHEL® in partial-thickness burn injuries. The study focused on patient pain score, healing time, analysis of wound bed, ease of care, and treatment costs.
Schwarze et al. Burns. 2007 Nov;33(7):850-4.
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A prospective, randomized, two center clinical study was conducted to evaluate the impact on wound healing of SUPRATHEL® in donor sites of split-thickness skin grafts.
Trabold et al. Wound Repair Regen. 2003 Nov-Dec;11(6):504-9.
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Lactate induces a biochemical “perception” of hypoxia and instigates several signals that activate growth factor/cytokine signals while the continued presence of molecular oxygen allows endothelial cells and fibroblasts to reproduce and deposit collagen.
Uhlig et al. Burns. 2007 Mar;33(2):221-9.
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A new skin substitute was developed from a synthetic copolymer mainly based on DL-lactic acid; it is marketed as SUPRATHEL®. Within the scope of a bicentric study SUPRATHEL® was compared versus paraffin gauze intraindividually applied on split skin donor sites
Wagner et al. Wound Repair Regen. 2004 May-Jun;12(3):368-73.
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Increased proliferation of cultured human fibroblasts by exogenous lactate is mediated by oxidant production.